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Explainer | What is MASLD? Most common chronic liver disease affects up to 40% of adults

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Nalini Lakhani, a Hong Kong secondary school teacher, had never heard of metabolic dysfunction-associated steatotic liver disease (MASLD) until she got her diagnosis.

Few people have heard of it, even though it is the most common chronic liver disease worldwide.

There is a 95 per cent overlap in the diagnostic criteria for the two conditions, says Dr Loey Mak Lung-yi, a Hong Kong-based specialist in gastroenterology and hepatology. Both involve having excessive fat in the liver, considered to be more than 5 per cent of the liver’s weight.

The shift in terminology from NAFLD to MASLD began in 2020 as doctors and experts gained a deeper understanding of the disease’s key driver: metabolic dysfunction.

That includes conditions such as obesity, diabetes and dyslipidemia, the latter of which is characterised by high levels of fats – or lipids, including cholesterol and triglycerides – in the blood.

Nalini Lakhani had never heard of metabolic dysfunction-associated steatotic liver disease until she got her diagnosis. Photo: Nalini Lakhani

Nalini Lakhani had never heard of metabolic dysfunction-associated steatotic liver disease until she got her diagnosis. Photo: Nalini Lakhani

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